From the downtown ferry dock, drive up Center Avenue and cross the main intersection to the entrance of Thorsheim Street (next to McDonald's). St. James is at the top of the first hill.
From Pier 2, get onto the highway (Rezanof Drive) and turn right towards town. Turn left at the main intersection to get onto Mill Bay Road, then left again almost immediately onto Thorsheim.
From the airport, turn right on Rezanof Drive and follow it into town to reach the main intersection and your turn.